The following is a summary of acts which authorized boundary changes for Grainger County.
- Acts of 1845-46, Chapter 47, Section 4, altered the line between Jefferson and Grainger counties to place the land of J. N. Shannon in Jefferson County.
- Acts of 1847-48, Chapter 51, altered the line between Grainger and Jefferson counties to place the land of James Barton in Grainger County.
- Acts of 1847-48, Chapter 197, altered the line between Grainger and Jefferson counties to place the land of William Rice in Jefferson County.
- Acts of 1849-50, Chapter 69, altered the line between Grainger, Hawkins, and Jefferson to place the land of Obadiah Boaz in Grainger County and, also, altered the line between Grainger and Hawkins to place the farm of David Harris in Grainger County.
- Acts of 1851-52, Chapter 221, altered the line between the counties of Grainger and Knox to place in Knox County lands owned by James Cannon, Hardin W. Mynatt, Preston Mynatt, and Preston Mitchel.
- Acts of 1855-56, Chapter 161, altered the line between Grainger and Jefferson to place the farm of Charles E. Eckle in Jefferson County.
- Public Acts of 1857-58, Chapter 47, altered the line between Grainger and Jefferson to place the farms of William Taylor and Jessee Hunt in Jefferson County.
- Private Acts of 1860, Chapter 135, Section 7, altered the line between Grainger and Jefferson counties to place the farm of Mrs. Nancy Senter in Grainger.
- Public Acts of 1869-70, Chapter 48, altered the line between Grainger and Hawkins Counties to place the farm of John Coldwell in Hawkins County.
- Public Acts of 1869-70, Chapter 48, altered the line between Grainger and Knox counties to place the land of James McBee in Grainger County.
- Public Acts of 1869-70, Chapter 88, Section 8, altered the line between Grainger and Claiborne counties to place Grissom's Island, situated in the Clinch River and owned by George Johnson and Isaac West in Claiborne County.
- Public Acts of 1870-71, Chapter 118, altered the line between Grainger and Union counties to place the farms of James Dyer Sr. and James Dyer, Jr. in Union County.
- Public Acts of 1873, Chapter 70, altered the line between Grainger and Union counties to place the farms of J. J. Sellers, Pryor Dyer, James Vitetoe and E. D. Hill in Union County.
- Public Acts of 1877, Chapter 149, altered the line between Grainger and Hawkins counties to place the farm of Anderson Mullens in Grainger County.
- Public Acts of 1879, Chapter 56, altered the line between Grainger and Jefferson counties to place the island farm of John Vance, situated in the Holston River in Jefferson County.
- Public Acts of 1887, Chapter 49, altered the line between Grainger and Union counties to place the farm of J. T. Inkleboyer in Grainger County. This act was repealed by Public Acts of 1895, Chapter 188, which was in turn repealed by Private Acts of 1901, Chapter 361, thus apparently reviving the act. The act was repealed again by Acts of 1905, Chapter 71.
- Public Acts of 1889, Chapter 24, altered the line between Grainger and Union counties to place the lands of G. W. Hollinsworth, William Hollinsworth, B. M. McPhetridge, and B. Shelton in Grainger County.
- Public Acts of 1891, Chapter 154, altered the line between Grainger and Hancock counties to place the lands of J. D. Greene and William T. Greene in Hancock County.
- Public Acts of 1895, Chapter 104, altered the line between Grainger and Union counties to place the farm of V. W. Capps in Union County.
- Public Acts of 1899, Chapter 233, altered the line between Grainger and Union Counties to place the farms of J. A. Popejoy and E. E. Dyer in Union County. Private Acts of 1901, Chapter 310, repealed this act.
- Private Acts of 1901, Chapter 191, altered the line between Grainger and Knox counties to place the farm of James M. Shipe in Grainger County.
- Acts of 1903, Chapter 527, altered the line between Grainger and Hancock counties to place the farm of John Wolf in Grainger County.
- Acts of 1907, Chapter 227, altered the line between Grainger and Jefferson counties to place "Old McKinney Island" owned by E. G. Price, James Vance and Samuel Vance, and situated in the Holstein River in Jefferson County.
- Acts of 1907, Chapter 386, altered the line between Grainger and Jefferson counties to place "Vance's Island" in Grainger County.
- Private Acts of 1911, Chapter 245, altered the line between Grainger and Hancock Counties to place the farm of J. N. Dalton in Grainger County.
- Private Acts of 1919, Chapter 394, altered the line between Grainger and Union counties to place the farms of C. M. Cabbage, Lafayette Hamilton and Jess Rush in Union County.
- Private Acts of 1919, Chapter 739, altered the line between Grainger and Knox counties to place the lands of I. L. Moore and Sallie Moore in Knox County.
- Private Acts of 1927, Chapter 741, altered the line between Grainger County and Knox County to place the farm of Viola E. Hamilton in Knox County.
- Private Acts of 1933, Chapter 637, altered the line between Grainger and Knox counties to place the farm of A. C. Panatt in Knox County.